Immunologic and autoradiographic localisation of the Na+, K(+)-ATPase in articular cartilage: upregulation in response to changes in extracellular Na+ concentration.

Journal article

The maintenance of a relatively low intracellular Na+:K+ ratio is essential for the functioning of a wide range of cellular processes, and is achieved principally by the activity of the membrane-bound Na+, K(+)-ATPase. Chondrocytes, the cells of articular cartilage, exist in an ionic environment where the free extracellular [Na+] is higher (250-400 mM) than that of most other tissues (approximately 140 mM) owing to the fixed negative charges on glycosaminoglycans in the extracellular matrix. ...

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Authors: Mobasheri, A; Hall, A; Urban, J; France, S; Smith, A

• Publication status: Published
• Journal: international journal of biochemistry and cell biology
• Volume: 29
• Issue: 4
• Pages: 649-657
• Publication date: 1997-04-01
• DOI: 10.1016/s1357-2725(96)00150-1
• EISSN: 1878-5875
• ISSN: 1357-2725
• Language: English
• Keywords: Extracellular Space; Sodium; Cattle; Up-Regulation; Chondrocytes; Autoradiography; Cartilage, Articular; Animals; Sodium-Potassium-Exchanging ATPase; Microscopy, Fluorescence