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Immunologic and autoradiographic localisation of the Na+, K(+)-ATPase in articular cartilage: upregulation in response to changes in extracellular Na+ concentration.

Abstract:

The maintenance of a relatively low intracellular Na+:K+ ratio is essential for the functioning of a wide range of cellular processes, and is achieved principally by the activity of the membrane-bound Na+, K(+)-ATPase. Chondrocytes, the cells of articular cartilage, exist in an ionic environment where the free extracellular [Na+] is higher (250-400 mM) than that of most other tissues (approximately 140 mM) owing to the fixed negative charges on glycosaminoglycans in the extracellular matrix. ...

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Publication status:
Published

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Authors


Mobasheri, A More by this author
France, SJ More by this author
Journal:
The international journal of biochemistry and cell biology
Volume:
29
Issue:
4
Pages:
649-657
Publication date:
1997-04-05
DOI:
EISSN:
1878-5875
ISSN:
1357-2725
URN:
uuid:a452693d-f30e-4e4b-bcdd-8b2e77a43116
Source identifiers:
433366
Local pid:
pubs:433366

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