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The mechanism of decomposition of N-methyl-N-nitrosourea (MNU) in water and a study of its reactions with 2'-deoxyguanosine, 2'-deoxyguanosine 5'-monophosphate and d(GTGCAC)

Abstract:

The carcinogenicity of N-methyl-N-nitrosourea (MNU) arises, from its ability to methylate DNA, This occurs in an aqueous environment and therefore an appreciation of the mode of decomposition of MNU in water is essential to understanding the mechanism of DNA methylation and its base sequence dependence. The kinetics of MNU hydrolyses are shown to be first order in MNU with a steep rise in rate above pH 8. Using NMR for in situ monitoring of reaction intermediates and products from hydrolyses ...

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Publication status:
Published

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Journal:
TETRAHEDRON
Volume:
53
Issue:
11
Pages:
4063-4082
Publication date:
1997-03-17
DOI:
ISSN:
0040-4020
URN:
uuid:a44f0bd6-e675-444e-b5e5-3266c4fb9046
Source identifiers:
115948
Local pid:
pubs:115948

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