- Abstract:
-
The carcinogenicity of N-methyl-N-nitrosourea (MNU) arises, from its ability to methylate DNA, This occurs in an aqueous environment and therefore an appreciation of the mode of decomposition of MNU in water is essential to understanding the mechanism of DNA methylation and its base sequence dependence. The kinetics of MNU hydrolyses are shown to be first order in MNU with a steep rise in rate above pH 8. Using NMR for in situ monitoring of reaction intermediates and products from hydrolyses ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/S0040-4020(97)00018-5
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- Journal:
- TETRAHEDRON
- Volume:
- 53
- Issue:
- 11
- Pages:
- 4063-4082
- Publication date:
- 1997-03-17
- DOI:
- ISSN:
-
0040-4020
- URN:
-
uuid:a44f0bd6-e675-444e-b5e5-3266c4fb9046
- Source identifiers:
-
115948
- Local pid:
- pubs:115948
- Copyright date:
- 1997
Journal article
The mechanism of decomposition of N-methyl-N-nitrosourea (MNU) in water and a study of its reactions with 2'-deoxyguanosine, 2'-deoxyguanosine 5'-monophosphate and d(GTGCAC)
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