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Reconstitution of the Epstein-Barr virus-specific cytotoxic T-lymphocyte response following T-cell-depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation.

Abstract:

The recovery of circulating antigen-specific T-cell immunity to Epstein-Barr virus (EBV) was determined in ELIspot assays following allogeneic myeloablative or nonmyeloablative stem cell transplantation (MST/NST). In 8 of 12 MST patients receiving an alemtuzumab-treated graft, the frequency of the EBV-specific reactivities was similar to or greater than that seen in the healthy controls. A response was detectable in 3 of 6 and 6 of 9 patients by 3 and 6 months, respectively, and in all patien...

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Publication status:
Published

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Publisher copy:
10.1182/blood.v102.3.839

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Journal:
Blood
Volume:
102
Issue:
3
Pages:
839-842
Publication date:
2003-08-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
26487

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