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Journal article

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.

Abstract:

Biallelic CEBPA mutations and FMS-like tyrosine kinase receptor 3 (FLT3) length mutations are frequently identified in human acute myeloid leukemia (AML) with normal cytogenetics. However, the molecular and cellular mechanisms of oncogene cooperation remain unclear because of a lack of disease models. We have generated an AML mouse model using knockin mouse strains to study cooperation of an internal tandem duplication (ITD) mutation in the Flt3 gene with commonly observed CCAAT/enhancer bind...

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Publication status:
Published

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Publisher copy:
10.1038/leu.2012.37

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Journal:
Leukemia
Volume:
26
Issue:
7
Pages:
1527-1536
Publication date:
2012-07-05
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
URN:
uuid:a442ada0-c693-40fa-acfc-04be0b4865a3
Source identifiers:
344826
Local pid:
pubs:344826

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