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Pharmacokinetic optimisation of inhaled steroid therapy in asthma.

Abstract:

The recognition that asthma has a large inflammatory component has led to the use of steroids in its treatment. The adverse systemic effects of the drugs have promoted the development of inhaled steroids with a high topical to systemic potency ratio. The 2 most widely used agents are beclomethasone dipropionate and budesonide. Budesonide has a longer plasma elimination half-life than beclomethasone dipropionate but a higher topical to systemic potency ratio. These agents have been shown to be...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Journal:
Clinical pharmacokinetics
Volume:
25
Issue:
2
Pages:
126-135
Publication date:
1993-08-05
DOI:
ISSN:
0312-5963
URN:
uuid:a436eb73-bc35-43aa-aadf-296516740a4a
Source identifiers:
435414
Local pid:
pubs:435414
Language:
English
Keywords:

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