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Independent effects of circulating glucose, insulin and NEFA on cardiac triacylglycerol accumulation and myocardial insulin resistance in a swine model

Abstract:

Aims/hypothesis: Cardiac steatosis and myocardial insulin resistance elevate the risk of cardiac complications in obesity and diabetes. We aimed to disentangle the effects of circulating glucose, insulin and NEFA on myocardial triacylglycerol (TG) content and myocardial glucose uptake. Methods: Twenty-two pigs were stratified according to four protocols: low NEFA + low insulin (nicotinic acid), high NEFA + low insulin (fasting) and high insulin + low NEFA ± high glucose (hyperinsulinaemia-hyp...

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Publisher copy:
10.1007/s00125-014-3307-8

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Publisher:
Springer Verlag
Journal:
Diabetologia
Volume:
57
Issue:
9
Pages:
1937-1946
Publication date:
2014-01-01
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:a4287de3-9eea-4c2d-9231-14dba22053f2
Source identifiers:
481246
Local pid:
pubs:481246

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