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The emerging role of Mule and ARF in the regulation of base excision repair

Abstract:

The ARF (Alternative Reading Frame) protein is encoded in the Ink4a locus of human chromosome 9 that is frequently mutated in cancer cells. It was recently demonstrated that ARF is induced in response to DNA damage and inhibits, by direct interaction, the E3 ubiquitin ligase Mule that regulates p53 protein levels. Mule inhibition leads to p53 accumulation and activates cellular DNA damage responses. Mule has also recently been identified as a major E3 ubiquitin ligase involved in the regulati...

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Authors


Khoronenkova, SV More by this author
Dianov, GL More by this author
Journal:
FEBS Letters
Volume:
585
Issue:
18
Pages:
2831-2835
Publication date:
2011-09-16
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:a41f2ab4-d5f6-486e-baff-45047a1b94cf
Source identifiers:
179865
Local pid:
pubs:179865

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