Specialised transcription factories

Thesis

The intimate relationship between the higher-order chromatin organisation and the regulation of gene expression is increasingly attracting attention in the scientific community. Thanks to high-resolution microscopy, genome-wide molecular biology tools (3C, ChIP-on-chip), and bioinformatics, detailed structures of chromatin loops, territories, and nuclear domains are gradually emerging. However, to fully reveal a comprehensive map of nuclear organisation, some fundamental questions remain to b...

Expand abstract

Authors: Xu, M

• Publication date: 2008
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: transcription factories; chromosome conformation; fluorescence microscopy; genome organisation; nuclear organisation; transcription; transcription wave; chromosome organisation; chromosome; FISH; in situ hybridisation; 3C; microarray; genome; chromosome structure; genomic; gene expression
• Subjects: Biochemistry; Life Sciences; Mammalian chromosome; Microscopy; Cell Biology (see also Plant sciences); Pathology; Genetics (life sciences); Molecular genetics; Medical Sciences; Molecular biophysics (biochemistry); Biology (medical sciences); Biology; Genetics (medical sciences)