Journal article
Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline
- Abstract:
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Adult male germline stem cells (spermatogonia) proliferate by mitosis and, after puberty, generate spermatocytes that undertake meiosis to produce haploid spermatozoa. Germ cells are under evolutionary constraint to curtail mutations and maintain genome integrity. Despite constant turnover, spermatogonia very rarely form tumors, so-called spermatocytic tumors (SpT). In line with the previous identification of FGFR3 and HRAS selfish mutations in a subset of cases, candidate gene screening of 2...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 7.0MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0178169
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Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS One More from this journal
- Volume:
- 12
- Issue:
- 5
- Pages:
- e0178169
- Publication date:
- 2017-05-22
- Acceptance date:
- 2017-05-08
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:698031
- UUID:
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uuid:a4121b45-ab08-49b7-8d42-7a9b275bad54
- Local pid:
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pubs:698031
- Deposit date:
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2017-06-09
Terms of use
- Copyright holder:
- Giannoulatou et al
- Copyright date:
- 2017
- Notes:
- © 2017 Giannoulatou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
- Licence:
- CC Attribution (CC BY)
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