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Journal article

Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patients

Abstract:

We examined the influence that rare variants and low-frequency polymorphisms in the cancer candidate gene CCND1 have on the development of multiple intestinal adenomas and the early onset of colorectal cancer. Individuals with <100 multiple polyps and patients with colorectal cancer diagnosed before 50 years of age were recruited in UK, and screened for sequence changes in the coding and regulatory regions of CCND1. A set of about 800 UK control individuals was genotyped for the variants d...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/jhg.2010.144

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Department:
Oxford, SSD, Anthropology, Human Sciences Institute
Role:
Author
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Wellcome Trust More from this funder
Cancer Research UK More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Journal of Human Genetics Journal website
Volume:
56
Pages:
58–63
Publication date:
2015-11-25
DOI:
ISSN:
1435-232X and 1434-5161
Pubs id:
pubs:175146
URN:
uri:a40f67e9-b411-4efd-9443-98486c7490af
UUID:
uuid:a40f67e9-b411-4efd-9443-98486c7490af
Local pid:
pubs:175146

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