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Gene expression in mouse thyrotrope adenoma: transcription elongation factor stimulates proliferation

Abstract:

Thyrotrope hyperplasia and hypertrophy are common responses to primary hypothyroidism. To understand the genetic regulation of these processes, we studied gene expression changes in the pituitaries of Cga-/- mice, which are deficient in the common alpha subunit of TSH, LH and FSH. These mice have thyrotrope hypertrophy and hyperplasia and develop thyrotrope adenoma. We report that cell proliferation is increased, but the expression of most stem cell markers is unchanged. The alpha subunit is ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Gergics, P More by this author
Camper, SA More by this author
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Funding agency for:
Ajmal, A
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Funding agency for:
Camper, SA
Publisher:
Endocrine Society Publisher's website
Journal:
Endocrinology Journal website
Publication date:
2016-07-28
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:a4070fcd-0978-475b-8dd4-d1028b49c33b
Source identifiers:
634517
Local pid:
pubs:634517

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