OBJECTIVE: • To assess whether a seasonal change in prostate specific antigen (PSA) levels can be detected in men recruited to a large clinical trial. PATIENTS AND METHODS: • A total of 66 969 men aged 50-69 years were drawn from a large study conducted at general practices across the UK between 2002 and 2007. • Trigonometric algorithms and regression methods were used to assess the relationship between the time of year and serum PSA and blood pressure measurements. • We obtained local daily ...Expand abstract
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Seasonal variation in prostate-specific antigen levels: a large cross-sectional study of men in the UK.
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