Effects of intracellular magnesium on Kv1.5 and Kv2.1 potassium channels.

Journal article

We characterized the effects of intracellular Mg(2+) (Mg(2+) (i)) on potassium currents mediated by the Kv1.5 and Kv2.1 channels expressed in Xenopus oocytes. Increase in Mg(2+) (i) caused a voltage-dependent block of the current amplitude, apparent acceleration of the current kinetics (explained by a corresponding shift in the steady-state activation) and leftward shifts in activation and inactivation dependencies for both channels. The voltage-dependent block was more potent for Kv2.1 [diss...

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Authors: Tammaro, P; Smirnov, S; Moran, O

• Publication status: Published
• Journal: European biophysics journal : EBJ
• Volume: 34
• Issue: 1
• Pages: 42-51
• Publication date: 2005-02-01
• DOI: 10.1007/s00249-004-0423-2
• EISSN: 1432-1017
• ISSN: 0175-7571
• Language: English
• Keywords: Dose-Response Relationship, Drug; Xenopus laevis; Kv1.5 Potassium Channel; Oocytes; Shab Potassium Channels; Potassium Channels, Voltage-Gated; Intracellular Fluid; Ion Channel Gating; Magnesium; Animals; Membrane Potentials