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Clinical and psychometric correlates of dopamine D2 binding in depression.

Abstract:

BACKGROUND: Single photon emission tomography (SPET) with the dopamine D2/3 ligand 123I-IBZM gives a semi-quantitative estimate of dopamine binding. In depressed patients, we predicted evidence of reduced function, i.e. increased binding, particularly in more retarded patients. METHODS: Fifteen depressed patients with major depressive illness and 15 healthy, age- and sex- matched volunteerS were examined with a clinical and neuropsychological test battery and high resolution IBZM-SPET. Estima...

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Publisher copy:
10.1017/s0033291797005382

Authors


Ogilvie, AD More by this author
Goodwin, GM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Journal:
Psychological medicine
Volume:
27
Issue:
6
Pages:
1247-1256
Publication date:
1997-11-05
DOI:
EISSN:
1469-8978
ISSN:
0033-2917
URN:
uuid:a3e3c96c-8d16-415d-88c1-ca7782dee1e1
Source identifiers:
139308
Local pid:
pubs:139308

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