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Downregulation of caveolin-1 enhances fusion of human BeWo choriocarcinoma cells.

Abstract:

BACKGROUND: Fusion of placental villous cytotrophoblasts with the overlying syncytiotrophoblast is essential for the maintenance of successful pregnancy, and disturbances in this process have been implicated in pathological conditions such as pre-eclampsia and intra-uterine growth retardation. Caveolin-1 has been shown to be expressed in human villous cytotrophoblast and to be downregulated during fusion into syncytiotrophoblast but it is unclear whether it plays a role in this process. METH...

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Publication status:
Published

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Authors


Collett, GP More by this author
Linton, EA More by this author
Redman, CW More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Journal:
PloS one
Volume:
5
Issue:
5
Pages:
e10529
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:a3dc9f36-828e-4d02-811e-bbbf2cbd751d
Source identifiers:
248258
Local pid:
pubs:248258

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