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Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer.

Abstract:

Major histocompatibility complex (MHC) class I molecules present peptides derived from the endogenous protein pool to cytotoxic T lymphocytes, which can thus recognize intracellular antigen. This pathway may depend on a transporter (PSF1) to mediate entry of the cytosolic peptides into a pre-Golgi compartment where they bind to class I heavy chains and promote their stable assembly with beta 2-microglobulin. There is, however, only indirect support for this function of PSF1. Here we show that...

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Publication status:
Published

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Publisher copy:
10.1038/355644a0

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Colonna, M More by this author
Cresswell, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
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Journal:
Nature
Volume:
355
Issue:
6361
Pages:
644-646
Publication date:
1992-02-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:a3c9fd12-d738-4918-8fdc-ef986edeb6c5
Source identifiers:
32851
Local pid:
pubs:32851

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