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Journal article

Duchenne muscular dystrophy and dystrophin: pathogenesis and opportunities for treatment.

Abstract:

Duchenne muscular dystrophy (DMD) is caused by mutations in the gene that encodes the 427-kDa cytoskeletal protein dystrophin. Increased knowledge of the function of dystrophin and its role in muscle has led to a greater understanding of the pathogenesis of DMD. This, together with advances in the genetic toolkit of the molecular biologist, are leading to many different approaches to treatment. Gene therapy can be achieved using plasmids or viruses, mutations can be corrected using chimaerapl...

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Publication status:
Published

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Publisher copy:
10.1038/sj.embor.7400221

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
EMBO reports
Volume:
5
Issue:
9
Pages:
872-876
Publication date:
2004-09-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:a3c2bcda-02c0-42e7-996a-0a97fd19902a
Source identifiers:
106157
Local pid:
pubs:106157

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