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Journal article

The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: a new repertoire evolves over 12 months.

Abstract:

Mycobacterium bovis bacille Calmette Guerin vaccination protects against pulmonary tuberculosis in the United Kingdom but not in Malawi. We investigated whether a difference in the clonal T-cell response to BCG vaccination might account for this. The results of clonal analysis were compared to those obtained by skin testing and in a whole blood interferon gamma assay. Pre-vaccination antigen specific T-cell clones were detected, but the majority of clones present 12 months after vaccination w...

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Journal:
Vaccine
Volume:
24
Issue:
14
Pages:
2617-2626
Publication date:
2006-03-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:a3c1a0cd-aa23-4714-8085-970152d840e9
Source identifiers:
33358
Local pid:
pubs:33358

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