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Differential expression of calcineurin A subunit mRNA isoforms during rat hippocampal and cerebellar development.

Abstract:

Calcineurin (protein phosphatase 2B) is a calcium-dependent serine-threonine phosphatase. It has diverse roles and is centrally involved in synaptic plasticity. The catalytic A subunit of calcineurin has three isoforms, alpha, beta and gamma. Their expression and ontogeny in the brain has not been systematically investigated; such data become important with a report that PPP3CC, the gene encoding calcineurin Agamma, is a susceptibility gene for schizophrenia, and the finding that its expressi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
The European journal of neuroscience
Volume:
22
Issue:
12
Pages:
3017-3024
Publication date:
2005-12-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:a3bdff85-3709-4262-94c7-719290ddd03e
Source identifiers:
97955
Local pid:
pubs:97955

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