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Human cleavage factor I (CFIm) and its role in alternative polyadenylation of pre-mRNA

Abstract:

For many human protein-coding genes, alternative cleavage and polyadenylation (APA) of pre-mRNA generates distinct 3' untranslated regions (3'UTRs) with differing regulatory potential. Widespread 3'UTR shortening via APA occurs in proliferative cell states, including cancer, where it can lead to oncogene overexpression. There has therefore been significant interest in identifying factors which influence poly(A) site choice in different physiological states. The multi-subunit human cleavage...

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Division:
MSD
Department:
Pathology Dunn School
Department:
Pathology
Role:
Author

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Department:
Pathology
Role:
Supervisor
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Funding agency for:
Hardy, J
Grant:
C38302/A13012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:a3ba5d10-b3fa-4ab7-9709-a0d642e21543
Deposit date:
2018-03-16

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