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Journal article

Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.

Abstract:
The rare variant hypothesis postulates that genetic susceptibility to colorectal neoplasia within the general population is due to a number of low frequency variants in a variety of different genes. Each variant confers a moderate, but detectable, increase in relative risk of developing the disease. Recent evidence suggests that a quarter of patients with multiple adenomatous polyps are due to rare but functionally important variants in just five genes.
Publication status:
Published

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Publisher copy:
10.4161/cc.4.4.1591

Authors


Journal:
Cell cycle (Georgetown, Tex.)
Volume:
4
Issue:
4
Pages:
521-525
Publication date:
2005-04-05
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
URN:
uuid:a3b94e1d-4270-470d-98a3-6ea155933317
Source identifiers:
178375
Local pid:
pubs:178375

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