- Abstract:
- The rare variant hypothesis postulates that genetic susceptibility to colorectal neoplasia within the general population is due to a number of low frequency variants in a variety of different genes. Each variant confers a moderate, but detectable, increase in relative risk of developing the disease. Recent evidence suggests that a quarter of patients with multiple adenomatous polyps are due to rare but functionally important variants in just five genes.
- Publication status:
- Published
- Publisher copy:
- 10.4161/cc.4.4.1591
-
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- Journal:
- Cell cycle (Georgetown, Tex.)
- Volume:
- 4
- Issue:
- 4
- Pages:
- 521-525
- Publication date:
- 2005-04-05
- DOI:
- EISSN:
-
1551-4005
- ISSN:
-
1538-4101
- URN:
-
uuid:a3b94e1d-4270-470d-98a3-6ea155933317
- Source identifiers:
-
178375
- Local pid:
- pubs:178375
- Copyright date:
- 2005
Journal article
Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.
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