- Abstract:
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Wnt morphogens control embryonic development and adult tissue homeostasis. Deregulation of the Wnt signalling pathway leads to human diseases. This thesis covers work on two antagonists of the Wnt signalling pathway, Wnt inhibitory factor 1 (WIF-1) (Chapters 1 to 5) and secreted Frizzled-related protein 1 (sFRP-1) (Chapters 1 and 6). In vertebrates the N-terminal WIF domain of the six-domain WIF-1 and the cysteine-rich domain of the two-domain sFRP-1 bind to Wnt proteins and inhibit signal...
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- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Copyright holder:
- Tomas Malinauskas
- Copyright date:
- 2012
Thesis
Structural and functional studies of Wnt signalling pathway antagonists
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