Thesis
Structural and functional studies of Wnt signalling pathway antagonists
- Abstract:
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Wnt morphogens control embryonic development and adult tissue homeostasis. Deregulation of the Wnt signalling pathway leads to human diseases. This thesis covers work on two antagonists of the Wnt signalling pathway, Wnt inhibitory factor 1 (WIF-1) (Chapters 1 to 5) and secreted Frizzled-related protein 1 (sFRP-1) (Chapters 1 and 6). In vertebrates the N-terminal WIF domain of the six-domain WIF-1 and the cysteine-rich domain of the two-domain sFRP-1 bind to Wnt proteins and inhibit signal...
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Funding
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:a3b71f18-9b90-408a-a5b5-2611e4ae2102
- Deposit date:
- 2016-11-15
Terms of use
- Copyright holder:
- Malinauskas, T
- Copyright date:
- 2012
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