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Thesis

Structural and functional studies of Wnt signalling pathway antagonists

Abstract:

Wnt morphogens control embryonic development and adult tissue homeostasis. Deregulation of the Wnt signalling pathway leads to human diseases. This thesis covers work on two antagonists of the Wnt signalling pathway, Wnt inhibitory factor 1 (WIF-1) (Chapters 1 to 5) and secreted Frizzled-related protein 1 (sFRP-1) (Chapters 1 and 6). In vertebrates the N-terminal WIF domain of the six-domain WIF-1 and the cysteine-rich domain of the two-domain sFRP-1 bind to Wnt proteins and inhibit signal...

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Institution:
University of Oxford
Research group:
Prof. Edith Yvonne Jones
Oxford college:
Jesus College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Division of Structural Biology
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Author

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Role:
Supervisor
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Funding agency for:
Tomas Malinauskas
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral

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