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Sugar-protein connectivity impacts on the immunogenicity of site-selective salmonella O-antigen glycoconjugate vaccines

Abstract:

A series of glycoconjugates with defined connectivity were synthesized to investigate the impact of coupling Salmonella typhimurium O-antigen to different amino acids of CRM197 protein carrier. In particular, two novel methods for site-selective glycan conjugation were developed to obtain conjugates with single attachment site on the protein, based on chemical modification of a disulfide bond and pH-controlled transglutaminase-catalyzed modification of lysine, respectively. Importantly, conju...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/anie.201506112

Authors


Stefanetti, G More by this author
Robinson, Z More by this author
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Publisher:
Wiley Online Library Publisher's website
Journal:
Angewandte Chemie - International Edition Journal website
Volume:
54
Issue:
45
Pages:
13198-13203
Publication date:
2010-04-29
Acceptance date:
2014-12-17
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:a3a38c1f-a264-4d80-8eca-aa216e336551
Source identifiers:
574390
Local pid:
pubs:574390
Keywords:

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