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Acute isovolemic hemodilution triggers proinflammatory and procoagulatory endothelial activation in vital organs: role of erythrocyte aggregation.

Abstract:

OBJECTIVES: The essential role of erythrocytes as oxygen carriers is historically well established, but their function to aggregate and the consequences on the microcirculation is under debate. The pathogenic potential of low erythrocyte aggregation could be important for patients undergoing on-pump cardipopulmonary bypass. These patients are severely hemodiluted due to preoperative isovolemic hemodilution (IHD), circuit priming, and large fluid infusions perioperatively. Considering the vas...

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Publication status:
Published

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Publisher copy:
10.1080/10739680600745992

Authors


Morariu, AM More by this author
Maathuis, MH More by this author
Asgeirsdottir, SA More by this author
Leuvenink, HG More by this author
Boonstra, PW More by this author
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Journal:
Microcirculation (New York, N.Y. : 1994)
Volume:
13
Issue:
5
Pages:
397-409
Publication date:
2006
DOI:
EISSN:
1549-8719
ISSN:
1073-9688
URN:
uuid:a39e8231-a273-4cda-86eb-995bfa56b5da
Source identifiers:
190868
Local pid:
pubs:190868

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