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HLA-C as a mediator of natural killer and T-cell activation: spectator or key player?

Abstract:

The biochemical properties of the HLA-C antigen differ substantially from those of HLA-A and -B molecules. For this reason, HLA-C diversity and expression at the cell surface are much lower than its counterparts and in consequence HLA-C-restricted responses have been infrequently detected and described. In this review we summarise the key differences between HLA-C and other class I molecules and provide an update on natural killer and T-cell responses restricted by HLA-C. We also discuss the ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
Journal:
Immunology
Volume:
133
Issue:
1
Pages:
1-7
Publication date:
2011-05-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:a397ac4c-a062-4f05-9e38-a3277083bf98
Source identifiers:
120187
Local pid:
pubs:120187

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