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Cell cycle kinesis in lymphocytes in the diagnosis of Alzheimer's disease.

Abstract:

The currently available clinical diagnostic tools do not allow an accurate and reliable diagnosis of Alzheimer's disease (AD) in other than demented patients. Furthermore, they do not allow the identification of subjects with pre-clinical AD. Cell cycle regulatory failure in neurones appears to be a very early event in the pathogenesis of AD. Our earlier findings indicate that there is a specific failure of the G1/S transition checkpoint that may not be restricted to neurones alone. We tested...

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Publication status:
Published

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Authors


Combrinck, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
Neuroscience letters
Volume:
317
Issue:
2
Pages:
81-84
Publication date:
2002-01-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:a394a089-6c9d-4e54-80ad-3a16165c0544
Source identifiers:
111190
Local pid:
pubs:111190

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