- Abstract:
-
Sickness behavior in humans is characterized by low mood and fatigue, which have been suggested to reflect changes in motivation involving reorganization of priorities. However, it is unclear which specific processes underlying motivation are altered. We tested whether bacterial endotoxin E. coli lipopolysaccharide (LPS) affected two dissociable constructs of motivational behavior, ie, effort and reward sensitivity. After familiarization with 5 effort levels, participants made a series of acc...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 476.4kb)
-
- Publisher copy:
- 10.1038/npp.2017.231
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Neuropsychopharmacology Journal website
- Volume:
- 43
- Pages:
- 1107–1118
- Publication date:
- 2017-09-26
- Acceptance date:
- 2017-09-05
- DOI:
- EISSN:
-
1740-634X
- ISSN:
-
0893-133X
- Pubs id:
-
pubs:731869
- URN:
-
uri:a38ce40e-69ce-4146-ae1c-b3d8eb14a512
- UUID:
-
uuid:a38ce40e-69ce-4146-ae1c-b3d8eb14a512
- Local pid:
- pubs:731869
- Language:
- English
- Copyright holder:
- Draper et al.
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Journal article
Effort but not reward sensitivity is altered by acute sickness induced by experimental endotoxemia in humans
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