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Effort but not reward sensitivity is altered by acute sickness induced by experimental endotoxemia in humans

Abstract:

Sickness behavior in humans is characterized by low mood and fatigue, which have been suggested to reflect changes in motivation involving reorganization of priorities. However, it is unclear which specific processes underlying motivation are altered. We tested whether bacterial endotoxin E. coli lipopolysaccharide (LPS) affected two dissociable constructs of motivational behavior, ie, effort and reward sensitivity. After familiarization with 5 effort levels, participants made a series of acc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/npp.2017.231

Authors


van der Meer, JW More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
Pickkers, P More by this author
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Publisher:
Springer Nature Publisher's website
Journal:
Neuropsychopharmacology Journal website
Volume:
43
Pages:
1107–1118
Publication date:
2017-09-26
Acceptance date:
2017-09-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
Pubs id:
pubs:731869
URN:
uri:a38ce40e-69ce-4146-ae1c-b3d8eb14a512
UUID:
uuid:a38ce40e-69ce-4146-ae1c-b3d8eb14a512
Local pid:
pubs:731869
Language:
English

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