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Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice

Abstract:

Background: Gastrointestinal harm, known to occur with NSAIDs, is thought to be lower with NSAID and gastroprotective agent, and with inhibitors selective to cyclooxygenase-2 (coxibs) at usual plasma concentrations. We examine competing strategies for available evidence of reduced gastrointestinal bleeding in clinical trials and combine this evidence with evidence from clinical practice on whether the strategies work in the real world, whether guidance on appropriate prescribing is followed, ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2474-7-79

Authors


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Institution:
"University of Oxford", "University of Wales Swansea"
Department:
School of Health Sciences
More by this author
Institution:
University of Oxford
Department:
Pain Research
More by this author
Institution:
University of Wales Swansea
Department:
School of Health Sciences
More by this author
Institution:
University of Oxford
Department:
Pain Research
Pfizer Ltd. More from this funder
Oxford Pain Research Trust More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Musculoskeletal Disorders Journal website
Volume:
7
Pages:
Article: 79
Publication date:
2006-10-05
DOI:
ISSN:
1471-2474
URN:
uuid:a3874c0e-2b30-4a7d-a6ca-d23a6ae523b9
Local pid:
ora:2304

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