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The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD).

Abstract:

Objective To replicate and refine the reported association of ankylosing spondylitis (AS) with two non-synonymous single nucleotide polymorphisms (nsSNPs) on chromosome 16q22.1.

Methods Firstly, 730 independent UK patients with AS were genotyped for rs9939768 and rs6979 and allele frequencies were compared with 2879 previously typed historic disease controls. Secondly, the two data sets were combined in meta-analyses. Finally, 5 tagging SNPs, locate...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/ard.2009.115147

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Institution:
University of Oxford
Department:
Oxford, MSD, Institute for Musculoskeletal Sciences, Botnar Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Institute for Musculoskeletal Sciences, Botnar Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Institute for Musculoskeletal Sciences, Botnar Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Institute for Musculoskeletal Sciences, Botnar Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Institute for Musculoskeletal Sciences, Botnar Research Centre
Role:
Author
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Funding agency for:
Harvey, D
National Institute for Health More from this funder
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Publisher:
BMJ Publishing Group Ltd Publisher's website
Journal:
Annals of the rheumatic diseases Journal website
Volume:
69
Issue:
6
Pages:
1243-1246
Publication date:
2010-06-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:a380d76f-a4ec-4f4a-b7fb-73b173a44dcc
Source identifiers:
108333
Local pid:
pubs:108333

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