Bone stromal cells in pagetic bone and Paget's sarcoma express RANKL and support human osteoclast formation.

Journal article

Paget's disease is a focal disorder of bone remodelling, in which there is an increase in osteoclast formation. A rare complication of Paget's disease is the development of a sarcoma, most commonly an osteosarcoma. Osteoclast formation occurs in the presence of macrophage-colony stimulating factor and receptor activator for nuclear factor-kappaB ligand (RANKL), and it has been shown that bone stromal cells in Paget's disease can influence osteoclast formation by modulating the expression of R...

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Authors: Sun, S; Lau, Y; Itonaga, I; Sabokbar, A; Athanasou, N

• Publication status: Published
• Journal: Journal of pathology
• Volume: 209
• Issue: 1
• Pages: 114-120
• Publication date: 2006-05-01
• DOI: 10.1002/path.1953
• EISSN: 1096-9896
• ISSN: 0022-3417
• Language: English
• Keywords: Biological Factors; Gene Expression; Male; Glycoproteins; Aged; Coculture Techniques; Humans; Stromal Cells; Osteoprotegerin; Carrier Proteins; Osteosarcoma; Aged, 80 and over; Cells, Cultured; Reverse Transcriptase Polymerase Chain Reaction; Bone Neoplasms; Receptors, Tumor Necrosis Factor; Osteitis Deformans; RANK Ligand; Cell Communication; Receptors, Cytoplasmic and Nuclear; Osteoclasts; RNA, Neoplasm; RNA, Messenger; Receptor Activator of Nuclear Factor-kappa B; Membrane Glycoproteins