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Matrix delivery transdermal 17beta-estradiol for the prevention of bone loss in postmenopausal women. The International Study Group.

Abstract:

A total of 277 early postmenopausal women were enrolled in this placebo-controlled 2-year study to examine the efficacy of a matrix transdermal 17beta-estradiol system, at three different dosages (25, 50 and 75 mg/day) combined with sequential oral dydrogesterone 20 mg/day, in preventing bone loss. At 2 years, the difference from placebo in percentage change from baseline of L1-4 lumbar spine bone mineral density (BMD) (assessed by dual-energy X-ray absorptiometry) was 4.7% +/- 0.7% with estr...

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Publisher copy:
10.1007/s001980050159

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Stakkestad, JA More by this author
Radowicki, S More by this author
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Journal:
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Volume:
9
Issue:
4
Pages:
358-366
Publication date:
1999
DOI:
EISSN:
1433-2965
ISSN:
0937-941X
URN:
uuid:a3694a3c-e9f3-4336-a40f-ccde29c37de1
Source identifiers:
126560
Local pid:
pubs:126560

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