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Biochemical and cellular studies of the KDM6 sub-family of JmjC histone lysine demethylases

Abstract:

The JmjC domain containing histone lysine demethylases (JmjC-KDMs) are a family of epigenetic enzymes which regulate gene expression by catalysing demethylation of N-terminal lysines on histone tails. KDM6A and KDM6B catalyse demethylation of histone H3 trimethyllysine (H3K27Me3) on the tail of histone H3, activating gene expression. The KDM6 family have various roles in development and disease, including in hypoxic disease states such as cancer and atherosclerosis. The aim of this projec...

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Grant:
RE/08/004/23915
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Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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