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Glycomethanethiosulfonates: powerful reagents for protein glycosylation

Abstract:

Twelve novel glycomethanethiosulfonate (glyco-MTS) protein glycosylation reagents have been prepared. Their use in a controlled site-selective glycosylation strategy that combines site-directed mutagenesis with chemical modification allows protein glycosylation with concomitant control of (i) site, (ii) carbohydrate, (iii) anomeric stereochemistry, (iv) sugar to protein spacer arm nature and (v) degree of glycan protection. The ability of these highly selective and yet reactive reagents has b...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Maughan, MAT More by this author
Journal:
TETRAHEDRON-ASYMMETRY
Volume:
11
Issue:
1
Pages:
245-262
Publication date:
2000-01-28
DOI:
ISSN:
0957-4166
URN:
uuid:a359d75b-60ee-4c47-8d33-0252ce444800
Source identifiers:
52101
Local pid:
pubs:52101
Language:
English

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