On the kinetics of suicide substrates.

Journal article

We consider a realistic suicide substrate reaction which can be represented by four rate equations for the concentrations of the various molecules as functions of time. We present a general procedure to obtain accurate, approximate solutions analytically in terms of the rate equation parameters. This systematic technique provides more accurate approximations to the exact (numerical) solutions than other approximate methods which have been proposed based on a pseudo-steady state hypothesis.

Authors: Burke, M; Maini, P; Murray, J

• Publication status: Published
• Journal: Biophysical chemistry
• Volume: 37
• Issue: 1-3
• Pages: 81-90
• Publication date: 1990-08-01
• DOI: 10.1016/0301-4622(90)88009-h
• EISSN: 1873-4200
• ISSN: 0301-4622
• Language: English
• Keywords: Mathematics; Enzymes; Protein Binding; Kinetics; Enzyme Inhibitors; Models, Theoretical