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Antimalarial activity of KAF156 in falciparum and vivax malaria

Abstract:
Background: KAF156 belongs to a new class of antimalarials (imidazolopiperazines), with activity against asexual and sexual blood stages and the pre-erythrocytic liver stages of malaria parasites. Methods: We conducted a phase 2, open-label, two-part study in five centers in Thailand and Vietnam, to assess the antimalarial efficacy, safety, tolerability and pharmacokinetic profile of KAF156 in adult patients with acute P.vivax or P.falciparum malaria. Multipl... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1056/NEJMoa1602250

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Department:
Oxford, MSD, NDM, Tropical Medicine
More by this author
Department:
Oxford, MSD, NDM, Tropical Medicine
Uthaisin, C More by this author
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Wellcome Trust More from this funder
Medicines for Malaria Venture More from this funder
Publisher:
Massachusetts Medical Society Publisher's website
Journal:
New England Journal of Medicine Journal website
Volume:
375
Pages:
1152-1160
Publication date:
2016-09-22
Acceptance date:
2016-07-01
DOI:
ISSN:
1533-4406
Pubs id:
pubs:646365
URN:
uri:a34fe871-625d-49c1-ac81-ab58aa363157
UUID:
uuid:a34fe871-625d-49c1-ac81-ab58aa363157
Local pid:
pubs:646365

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