Pyronaridine-artesunate is a newly introduced artemisinin-based combination treatment which may be deployed together with primaquine. A single-dose, randomized, three-sequence crossover study was conducted in healthy Thai volunteers to characterize potential pharmacokinetic interactions between these drugs. Seventeen healthy adults received a single oral dose of primaquine alone (30 mg base) and were then randomized to receive pyronaridine-artesunate alone (540-180 mg) or pyronaridine-artesun...Expand abstract
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- American Society for Microbiology Publisher's website
- Antimicrobial agents and chemotherapy Journal website
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Copyright © 2015, Jittamala et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.
Pharmacokinetic interactions between primaquine and pyronaridine-artesunate in healthy adult Thai subjects.
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