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Journal article

Pharmacokinetic interactions between primaquine and pyronaridine-artesunate in healthy adult Thai subjects.

Abstract:

Pyronaridine-artesunate is a newly introduced artemisinin-based combination treatment which may be deployed together with primaquine. A single-dose, randomized, three-sequence crossover study was conducted in healthy Thai volunteers to characterize potential pharmacokinetic interactions between these drugs. Seventeen healthy adults received a single oral dose of primaquine alone (30 mg base) and were then randomized to receive pyronaridine-artesunate alone (540-180 mg) or pyronaridine-artesun...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.03829-14

Authors


Jittamala, P More by this author
Pukrittayakamee, S More by this author
Ashley, EA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Hanboonkunupakarn, B More by this author
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Medicines for Malaria Venture More from this funder
Wellcome Trust More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial agents and chemotherapy Journal website
Volume:
59
Issue:
1
Pages:
505-513
Publication date:
2015
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:a331d384-179b-428c-852e-043b40f19c1c
Source identifiers:
489534
Local pid:
pubs:489534
Language:
English

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