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Thesis

Macrophage-HIV interactions

Subtitle:
aptamers against the gp 120 surface envelope glycoprotein of the macrophage tropic strains of HIV-1
Abstract:

HIV-1 has evolved a number of strategies in response to current anti-retroviral drugs and the selection pressure of humoral and cellular immunity. In particular, R5 viral strains that are essential for AIDS pathogenesis are very resistant to neutralization by antibodies. Therefore, the aim of this thesis was to develop synthetic nucleic acid ligands, aptamers, against gp120 of an R5 strain of HIV-1, with a view of using aptamers...

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Institution:
University of Oxford
Department:
Medical Sciences Division

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Publication date:
2002
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603824037
URN:
uuid:a32becf2-bf5d-4428-b598-e8057d977fbd
Local pid:
td:603824037

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