Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification.

Journal article

Abstract:: Neural crest cells (NCCs) are highly motile embryonic stem cells that delaminate from the neuroectoderm early during vertebrate embryogenesis and differentiate at defined target sites into various essential cell types. To reach their targets, NCCs follow 1 of 3 sequential pathways that correlate with NCC fate. The firstborn NCCs travel ventrally alongside intersomitic blood vessels to form sympathetic neuronal progenitors near the dorsal aorta, while the lastborn NCCs migrate superficially be...
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Journal:: Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:: 106
Issue:: 15
Pages:: 6164-6169
Publication date:: 2009-04-01
DOI:: 10.1073/pnas.0811521106
EISSN:: 1091-6490
ISSN:: 0027-8424

Language:: English
Keywords:: Neuropilin-1

Animals

Signal Transduction

Mice

Female

Male

Semaphorin-3A

Gene Expression Regulation, Developmental

Cell Movement

Neural Crest
Pubs id:: pubs:428934
UUID:: uuid:a3176339-bbf7-4a9f-a454-6bb47716197b
Local pid:: pubs:428934
Source identifiers:: 428934
Deposit date:: 2013-11-16

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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