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Journal article

Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener's granulomatosis.

Abstract:

Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8+tet(ramer)+ T-cells in WG. A marked proportion of these cells displayed a late differentiated "effector memory" T-cell phenotype with decrease...

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Publication status:
Published

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Authors


Lamprecht, P More by this author
Vargas Cuero, AL More by this author
Csernok, E More by this author
Voswinkel, J More by this author
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Journal:
Cellular immunology
Volume:
224
Issue:
1
Pages:
1-7
Publication date:
2003-07-05
DOI:
EISSN:
1090-2163
ISSN:
0008-8749
URN:
uuid:a305e3a7-415d-424e-90a7-b48ff441409f
Source identifiers:
28426
Local pid:
pubs:28426

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