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Functional properties of sodium channels do not depend on the cytoskeleton integrity.

Abstract:

Several observations suggest an interaction of the sodium channel alpha-subunit with the cytoskeletal structures. However, there is a wide variability in the results of experiments of heterologous expression in Xenopus oocytes and studies on mammalian cells are sometimes contradictory. In general, there has been no direct demonstration that ad hoc large perturbations of the cytoskeleton modify the intrinsic properties of the sodium channels expressed endogenously or heterologously in plasma m...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.2000.3398

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Biochemical and biophysical research communications
Volume:
275
Issue:
3
Pages:
839-844
Publication date:
2000-09-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:a3018502-041f-4e16-992e-4b2addd20ff1
Source identifiers:
386866
Local pid:
pubs:386866

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