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Thesis

Glucagon and glucose counterregulation: pancreatic α-cell function and dysfunction during hypoglycaemia

Abstract:

The glucagon-secreting α-cell is vital for the maintenance of glucose homeostasis and prevention of hypoglycaemia. Despite its importance many aspects of α-cell physiology are disputed. Thus, in this thesis, I aimed to elucidate several features of α-cell function – exploring how autonomic signals are integrated by the cell and how diabetes leads to its dysfunction.

The autonomic response to hypoglycaemia results in increased acetylcholine and adrenaline in the islet vicinity, which...

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Oxford, MSD, OCDEM
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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