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Amplified delivery of indium-111 to EGFR-positive human breast cancer cells.

Abstract:

A method is described to amplify the delivery of 111In to human breast cancer cells utilizing a novel human serum albumin-human EGF (HSA-hEGF) bioconjugate substituted preferentially in the HSA domain with multiple DTPA metal chelators for 111In. 111In-DTPA-HSA-hEGF exhibited a lower receptor-binding affinity than 111In-DTPA-hEGF but was rapidly and specifically bound, internalized and translocated to the nucleus in EGFR-positive MDA-MB-468 breast cancer cells. 111In-DTPA-HSA-hEGF was cytotox...

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Publication status:
Published

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Journal:
Nuclear medicine and biology
Volume:
28
Issue:
8
Pages:
895-902
Publication date:
2001-11-05
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
URN:
uuid:a2eb0f1b-52fb-480d-ab83-0d5fcb231b64
Source identifiers:
315095
Local pid:
pubs:315095

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