- Abstract:
-
A method is described to amplify the delivery of 111In to human breast cancer cells utilizing a novel human serum albumin-human EGF (HSA-hEGF) bioconjugate substituted preferentially in the HSA domain with multiple DTPA metal chelators for 111In. 111In-DTPA-HSA-hEGF exhibited a lower receptor-binding affinity than 111In-DTPA-hEGF but was rapidly and specifically bound, internalized and translocated to the nucleus in EGFR-positive MDA-MB-468 breast cancer cells. 111In-DTPA-HSA-hEGF was cytotox...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0969-8051(01)00262-1
-
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- Journal:
- Nuclear medicine and biology
- Volume:
- 28
- Issue:
- 8
- Pages:
- 895-902
- Publication date:
- 2001-11-05
- DOI:
- EISSN:
-
1872-9614
- ISSN:
-
0969-8051
- URN:
-
uuid:a2eb0f1b-52fb-480d-ab83-0d5fcb231b64
- Source identifiers:
-
315095
- Local pid:
- pubs:315095
- Language:
- English
- Keywords:
- Copyright date:
- 2001
Journal article
Amplified delivery of indium-111 to EGFR-positive human breast cancer cells.
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