Journal article

Amplified delivery of indium-111 to EGFR-positive human breast cancer cells.

Abstract:: A method is described to amplify the delivery of 111In to human breast cancer cells utilizing a novel human serum albumin-human EGF (HSA-hEGF) bioconjugate substituted preferentially in the HSA domain with multiple DTPA metal chelators for 111In. 111In-DTPA-HSA-hEGF exhibited a lower receptor-binding affinity than 111In-DTPA-hEGF but was rapidly and specifically bound, internalized and translocated to the nucleus in EGFR-positive MDA-MB-468 breast cancer cells. 111In-DTPA-HSA-hEGF was cytotox...
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Publication status:: Published

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APA Style

Wang, J., Chen, P., Su, Z., Vallis, K., Sandhu, J., Cameron, R., Hendler, A., & Reilly, R. (2001). Amplified delivery of indium-111 to EGFR-positive human breast cancer cells. Nuclear Medicine and Biology, 28(8), 895–902.

MLA Style

Wang, J., et al. “Amplified Delivery of Indium-111 to EGFR-Positive Human Breast Cancer Cells.” Nuclear Medicine and Biology, vol. 28, no. 8, 2001, pp. 895–902.

Chicago Style

Wang, J, P Chen, Z Su, K Vallis, J Sandhu, R Cameron, A Hendler, and R Reilly. 2001. “Amplified Delivery of Indium-111 to EGFR-Positive Human Breast Cancer Cells.” Nuclear Medicine and Biology 28 (8): 895–902.
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Publisher copy:: 10.1016/s0969-8051(01)00262-1

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+ Wang, J More by this author

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+ Chen, P More by this author

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+ Su, Z More by this author

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+ Vallis, K More by this author

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+ Sandhu, J More by this author

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Bibliographic Details

Journal:: Nuclear medicine and biology More from this journal
Volume:: 28
Issue:: 8
Pages:: 895-902
Publication date:: 2001-11-01
DOI:: 10.1016/s0969-8051(01)00262-1
EISSN:: 1872-9614
ISSN:: 0969-8051

Item Description

Language:: English
Keywords:: Humans

Indium Radioisotopes

Radioligand Assay

Breast Neoplasms

Serum Albumin

Receptor, Epidermal Growth Factor
Pubs id:: pubs:315095
UUID:: uuid:a2eb0f1b-52fb-480d-ab83-0d5fcb231b64
Local pid:: pubs:315095
Source identifiers:: 315095
Deposit date:: 2012-12-19

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Copyright date:: 2001

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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