Journal article
Tracing the action of IL-2 in tolerance to islet-specific antigen.
- Abstract:
-
Genetic variants of interleukin 2 (IL-2) and its receptor are associated with murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in controlling pancreatic islet-reactive T cells is unknown. Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression to diabetes, and its action upon diabetogenic islet-specific CD4 T cells can be tracked. We find that IL-2 is not required for Aire-dependent thymic clonal deletion of high-avidit...
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- Publisher copy:
- 10.1038/sj.icb.7100049
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Authors
Bibliographic Details
- Journal:
- Immunology and cell biology
- Volume:
- 85
- Issue:
- 4
- Pages:
- 338-342
- Publication date:
- 2007-06-01
- DOI:
- EISSN:
-
1440-1711
- ISSN:
-
0818-9641
- Source identifiers:
-
418829
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:418829
- UUID:
-
uuid:a2e656c5-6cbc-440c-9f48-62ce7d3bc45a
- Local pid:
- pubs:418829
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2007
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