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Tracing the action of IL-2 in tolerance to islet-specific antigen.

Abstract:

Genetic variants of interleukin 2 (IL-2) and its receptor are associated with murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in controlling pancreatic islet-reactive T cells is unknown. Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression to diabetes, and its action upon diabetogenic islet-specific CD4 T cells can be tracked. We find that IL-2 is not required for Aire-dependent thymic clonal deletion of high-avidit...

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Publisher copy:
10.1038/sj.icb.7100049

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Immunology and cell biology
Volume:
85
Issue:
4
Pages:
338-342
Publication date:
2007-06-05
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
URN:
uuid:a2e656c5-6cbc-440c-9f48-62ce7d3bc45a
Source identifiers:
418829
Local pid:
pubs:418829

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