Journal article
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.
- Abstract:
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Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuronal susceptibility in PD and is a feature of both familial and sporadic disease, as well as in toxin-induced Parkinsonism. Recently, the mechanisms by which PD-associated mitochondrial proteins phosphatase and tensin homolog deleted on chromoso...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Preview, Accepted manuscript, pdf, 820.2KB, Terms of use)
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- Publisher copy:
- 10.1016/j.tibs.2015.02.003
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Funding
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Trends in Biochemical Sciences More from this journal
- Volume:
- 40
- Issue:
- 4
- Pages:
- 200-210
- Publication date:
- 2015-03-08
- DOI:
- EISSN:
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1362-4326
- ISSN:
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0968-0004
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:510096
- UUID:
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uuid:a2dbf60e-828b-4f62-b5a2-036776e2882c
- Local pid:
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pubs:510096
- Source identifiers:
-
510096
- Deposit date:
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2016-01-28
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2015
- Notes:
- © 2015 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: [10.1016/j.tibs.2015.02.003]
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