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Journal article

Epistatic interactions between ancestral genotype and beneficial mutations shape evolvability in Pseudomonas aeruginosa.

Abstract:

The idea that interactions between mutations influence adaptation by driving populations to low and high fitness peaks on adaptive landscapes is deeply ingrained in evolutionary theory. Here we investigate the impact of epistasis on evolvability by challenging populations of two Pseudomonas aeruginosa clones bearing different initial mutations (in rpoB conferring rifampicin resistance, and the type IV pili gene network) to adaptation to a medium containing L-serine as the sole carbon source. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1111/evo.12958

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
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Funding agency for:
Gifford, DR
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Funding agency for:
Gifford, DR
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Funding agency for:
MacLean, RC
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Grant:
(FP7/2007-2013) Grant 281591
Publisher:
Wiley Publisher's website
Journal:
Evolution Journal website
Volume:
70
Issue:
7
Pages:
1659–1666
Publication date:
2016-05-27
DOI:
EISSN:
1558-5646
ISSN:
0014-3820
URN:
uuid:a2b7f6b5-755c-4342-ae05-52c07cec3f79
Source identifiers:
625020
Local pid:
pubs:625020

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