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Recombination within the human embryonic ζ-globin locus: A common ζ-ζ chromosome produced by gene conversion of the ψζ gene

Abstract:

The duplicated human embryonic α-like globin genes encode a 5′ functional zeta (ζ2) gene and a highly homologous pseudogene (ψζ1). We have identified chromosomes with a ζ2-ζ1 rather than a ζ2-ψζ1 arrangement by genomic mapping and oligonucleotide analysis. The DNA sequence of a cloned downstream ζ-like gene provides direct evidence for the conversion of a ψζ1→ζ1 gene, by a ζ2 gene. We present data suggesting that this gene conversion, which removed the only identifiable inactivating mutation ...

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Journal:
Cell
Volume:
42
Issue:
3
Pages:
809-819
Publication date:
1985-01-01
DOI:
ISSN:
0092-8674
URN:
uuid:a2a75cb3-974d-4f13-ad27-e65349bacc9e
Source identifiers:
95434
Local pid:
pubs:95434
Language:
English

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