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The DNA-polymerase-X family: controllers of DNA quality?

Abstract:
Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.
Publication status:
Published

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Publisher copy:
10.1038/nrm1530

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Shevelev, I More by this author
Hübscher, U More by this author
Journal:
Nature reviews. Molecular cell biology
Volume:
5
Issue:
12
Pages:
1038-1043
Publication date:
2004-12-05
DOI:
EISSN:
1471-0080
ISSN:
1471-0072
URN:
uuid:a29aa60c-16bf-47c3-a9a1-a65ab485c56e
Source identifiers:
417377
Local pid:
pubs:417377

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