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Journal article

T cell activation is determined by the number of presented antigens.

Abstract:
Antigen recognition is a key event during T cell activation. Here, we introduce nanopatterned antigen arrays that mimic the antigen presenting cell surface during T cell activation. The assessment of activation related events revealed the requirement of a minimal density of 90-140 stimulating major histocompatibility complex class II proteins (pMHC) molecules per μm(2). We demonstrate that these substrates induce T cell responses in a pMHC dose-dependent manner and that the number of presented pMHCs dominates over local pMHC density.
Publication status:
Published

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Publisher copy:
10.1021/nl403266t

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Journal:
Nano letters
Volume:
13
Issue:
11
Pages:
5619-5626
Publication date:
2013-01-01
DOI:
EISSN:
1530-6992
ISSN:
1530-6984
URN:
uuid:a294a58a-bdb4-4972-8d33-85c500b6cb36
Source identifiers:
453904
Local pid:
pubs:453904

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