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Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia.

Abstract:

Transmission of Plasmodium falciparum malaria is initiated by sexual stages in the mosquito. Anti-Pfs48/45 and anti-Pfs230 sexual stage antibodies that are ingested together with parasites can reduce parasite development and subsequently malaria transmission. Acquisition of sexual stage immunity was studied in a cohort of 102 non-immune Javanese individuals migrating to hyperendemic Papua Indonesia. Seroprevalence of antibodies against Pfs48/45 and Pfs230 and functional transmission-reducing ...

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Publication status:
Published

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Journal:
The American journal of tropical medicine and hygiene
Volume:
74
Issue:
3
Pages:
425-431
Publication date:
2006-03-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:a28cf057-2c5a-44aa-bf0d-5ab71d0d870f
Source identifiers:
81552
Local pid:
pubs:81552

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