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Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation.

Abstract:

A goal of molecular genetics is to understand the relationship between basic nuclear processes, epigenetic changes and the numerous proteins that orchestrate these effects. One such protein, ATRX, contains a highly conserved plant homeodomain (PHD)-like domain, present in many chromatin-associated proteins, and a carboxy-terminal domain which identifies it as a member of the SNF2 family of helicase/ATPases. Mutations in ATRX give rise to characteristic developmental abnormalities including se...

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Publication status:
Published

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Publisher copy:
10.1038/74191

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Journal:
Nature genetics
Volume:
24
Issue:
4
Pages:
368-371
Publication date:
2000-04-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:a2701a8e-752b-45e5-97b0-0476d8d38426
Source identifiers:
246350
Local pid:
pubs:246350

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